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-- -- -- c a t h -- home search browse download about support × find the structure of your protein protein structure is nearly always more conserved than sequence. as a result, when two proteins share a significant sequence similarity, it is extremely likely they will also share similar 3d structure. the following instructions demonstrate how to find significant cath structural domain matches on your own protein sequence. search go to "search by sequence" paste your protein sequence into the text box click "search" wait for your results to finish (should take less than 1 minute) results the results show the positions of the most similar cath domain structures matching your protein sequence each result has links to find out more about... the particular matching cath domain the superfamily to which the matching domain belongs close search now × investigate how domains have evolved cath-gene3d provides information on the evolutionary relationships of protein domains through sequence, structure and functional annotation data. the homologous superfamily (h) level of the cath hierarchical classification groups domains that are related by evolution ( find out more about the classification process ). a relatively small number of cath superfamilies have developed high levels of sequence, structural and functional diversity during evolution. despite high levels of structural diversity, these superfamily members are still observed to share a conserved structural core. the following are considered in the analysis of domain evolution: sequence diversity superfamily relatives are clustered at different degrees of domain sequence similarity: 35, 60, 95 and 100%. superfamilies are typically described as being diverse in sequence if they have multiple clusters at a sequence identity of 35%. the classification / domains tab on the cath superfamily web pages provides an interactive diagram for exploring all the different types of sequence clusters. structural diversity structural diversity in a superfamily can be measured by looking at the number of structurally-similar groups (or ssgs) that it contains. the superfamily superpositions tab on the cath-gene3d superfamily web pages demonstrate that even structurally diverse superfamilies have a common structural core. functional diversity superfamily relatives with similar sequence properties are clustered into functional families (or funfams). the funfams are useful in the prediction of function and in providing information on the evolution of function. close × investigate protein function proteins are typically composed of one or more building blocks, called domains. protein domains are generally considered as independently-folding units of structure. within a superfamily, cath-gene3d creates functional families (funfams) that aim to group together domains that share the same function. therefore, if a region of protein sequence provides a highly significant match to a particular cath-gene3d funfam, then there is a good chance they shares a similar function. to test this assertion, our function prediction pipeline (based on these funfams) was submitted to the critical assessment of protein function annotation (cafa). our method was ranked highly for accuracy of function prediction according to a number of different scoring methods. the following instructions demonstrate how to find function annotations for your own protein sequence. search go the "search by sequence" page. paste your protein sequence into the text box click "search" wait for your results to finish results the output of the web server provides: the best matches to cath-gene3d domain superfamilies and funfam ids for the query sequence the enzyme commission (ec) and gene ontology (go) annotations for the matching funfam(s). close search now × investigate conserved sites protein domain superfamilies in cath-gene3d have been subclassified into functional families (or funfams), which are groups of protein sequences and structures with a high probability of sharing the same function(s). therefore, the functionally important residues in a family are also expected to be highly conserved. information on conserved positions in cath-gene3d funfam alignments is shown through the alignment tab of the funfam webpages. conservation scores have been calculated using scorecons and columns in the alignment are coloured using a rainbow colour scheme, where the highly conserved residues are shown in red through to positions that are not conserved at all, shown in blue. the conservation scores are also mapped onto a representative protein domain structure. to investigate putative conserved sites for your protein sequence, run a sequence search against the funfams and click on the funfam match alignment page. close search now × what is cath-b? we aim to provide official releases of the cath classification every 12 months. this release process is important because is allows us to provide internal validation, extra annotations and analysis. however, it can mean that there is a time delay between new structures appearing in the pdb and the latest official cath release in order to address this issue: cath-b provides a limited amount of information for the very latest domain annotations (e.g. domain boundaries and superfamily classifications). this information is called cath-b close search now cath / gene3d v4.2 95 million protein domains classified into 6,119 superfamilies search core classification files for the latest version of cath-plus (v4.2) are now available to download . daily updates of our very latest classifications are also available . we are currently working on generating the cath-plus database for v4.2 which comprises all the extra derived data from the classification data. this includes: incorporation of the latest gene3d sequence and functional annotation data; updating the functional families (funfams) ; creating new superfamily superpositions ; producing structural clusters for each superfamily. we will update the web pages when this data is ready. 3d structure find out what 3d structure your protein adopts find out more go protein evolution learn about a particular protein family and how it evolved find out more protein function investigate the function of your protein find out more go conserved sites look at protein sites that are highly conserved and implicated in function find out more go download data download data files and query cath via webservices go learn more find out how cath is created and maintained, how to link to cath and more go c a t h -- what is cath-gene3d? cath is a classification of protein structures downloaded from the protein data bank. we group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor. search cath by text, id or keyword search cath by protein sequence search cath by pdb structure browse cath hierarchy cath release statistics cath tutorials gene3d uses the information in cath to predict the locations of structural domains on millions of protein sequences available in public databases. this allows us to include additional annotations to the cath-gene3d database such as functional information and active site residues. go to gene3d compare genomes download gene3d data learn how gene3d is created if you have any questions, comments or suggestions please get in touch via twitter , ask a question in our online forum or visit our support page . example pages pdb "2bop" domain "1cuka01" relatives of "1cuka01" superfamily "hups" functional family funfam alignment search for "enolase" superfamily comparison -- latest release statistics info cath-plus 4.2.0 cath (daily snapshot) pdb release 17-05-2017 06-07-2018 domains 434857 472362 superfamilies 6119 6767 annotated pdbs 131091 141705 gene3d v16 cellular genomes 19,471 -- protein sequences 52,073,853 cath domain predictions 95,665,487 citing this resource if you find the information in this resource useful, please consider usi

URL analysis for cathdb.info

http://www.cathdb.info/browse/tree
http://www.cathdb.info/search/by_structure
http://www.cathdb.info/wiki
http://www.cathdb.info/search
http://www.cathdb.info/about
http://www.cathdb.info/#modal-about-function
http://www.cathdb.info/#news
http://www.cathdb.info/browse
http://www.cathdb.info/search/by_sequence
http://www.cathdb.info/browse/superfamily_population
http://www.cathdb.info/#modal-about-superfamily
http://www.cathdb.info/#modal-what-is-cathb
http://www.cathdb.info/search/by_text
http://www.cathdb.info/wiki/doku/?id=privacy
http://www.cathdb.info/support
cath.biochem.ucl.ac.uk
ucl.ac.uk
gene3d.biochem.ucl.ac.uk

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Domain Name: CATHDB.INFO
Registry Domain ID: D10042537-LRMS
Registrar WHOIS Server:
Registrar URL: www.domainmonster.com
Updated Date: 2015-06-10T20:45:05Z
Creation Date: 2005-04-12T18:45:14Z
Registry Expiry Date: 2020-04-12T18:45:14Z
Registrar Registration Expiration Date:
Registrar: Mesh Digital Limited
Registrar IANA ID: 1390
Registrar Abuse Contact Email:
Registrar Abuse Contact Phone:
Reseller:
Domain Status: clientDeleteProhibited https://icann.org/epp#clientDeleteProhibited
Domain Status: clientTransferProhibited https://icann.org/epp#clientTransferProhibited
Domain Status: clientUpdateProhibited https://icann.org/epp#clientUpdateProhibited
Registry Registrant ID: C159244485-LRMS
Registrant Name: Ian Sillitoe
Registrant Organization: The CATH Group
Registrant Street: Room 627, Darwin Building
Registrant Street: Gower Street
Registrant City: London
Registrant State/Province: London
Registrant Postal Code: WC1E6BT
Registrant Country: GB
Registrant Phone: +44.442076792171
Registrant Phone Ext:
Registrant Fax:
Registrant Fax Ext:
Registrant Email: [email protected]
Registry Admin ID: C159244486-LRMS
Admin Name: Ian Sillitoe
Admin Organization: The CATH Group
Admin Street: Room 627, Darwin Building
Admin Street: Gower Street
Admin City: London
Admin State/Province: London
Admin Postal Code: WC1E6BT
Admin Country: GB
Admin Phone: +44.442076792171
Admin Phone Ext:
Admin Fax:
Admin Fax Ext:
Admin Email: [email protected]
Registry Tech ID: C159244488-LRMS
Tech Name: Ian Sillitoe
Tech Organization: The CATH Group
Tech Street: Room 627, Darwin Building
Tech Street: Gower Street
Tech City: London
Tech State/Province: London
Tech Postal Code: WC1E6BT
Tech Country: GB
Tech Phone: +44.442076792171
Tech Phone Ext:
Tech Fax:
Tech Fax Ext:
Tech Email: [email protected]
Registry Billing ID: C159244487-LRMS
Billing Name: Ian Sillitoe
Billing Organization: The CATH Group
Billing Street: Room 627, Darwin Building
Billing Street: Gower Street
Billing City: London
Billing State/Province: London
Billing Postal Code: WC1E6BT
Billing Country: GB
Billing Phone: +44.442076792171
Billing Phone Ext:
Billing Fax:
Billing Fax Ext:
Billing Email: [email protected]
Name Server: NS.123-REG.CO.UK
Name Server: NS2.123-REG.CO.UK
DNSSEC: unsigned
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>>> Last update of WHOIS database: 2017-07-15T17:01:56Z <<<

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  REGISTRAR Afilias Global Registry Services

SERVERS

  SERVER info.whois-servers.net

  ARGS cathdb.info

  PORT 43

  TYPE domain

DOMAIN

  NAME cathdb.info

  HANDLE D10042537-LRMS

  CREATED 2005-12-04

STATUS
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clientTransferProhibited https://icann.org/epp#clientTransferProhibited
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NSERVER

  NS.123-REG.CO.UK 212.67.202.2

  NS2.123-REG.CO.UK 62.138.132.21

OWNER

  HANDLE C159244485-LRMS

  NAME Ian Sillitoe

  ORGANIZATION The CATH Group

ADDRESS

STREET
Room 627, Darwin Building
Gower Street

  CITY London

  STATE London

  PCODE WC1E6BT

  COUNTRY GB

  PHONE +44.442076792171

  EMAIL [email protected]

ADMIN

  HANDLE C159244486-LRMS

  NAME Ian Sillitoe

  ORGANIZATION The CATH Group

ADDRESS

STREET
Room 627, Darwin Building
Gower Street

  CITY London

  STATE London

  PCODE WC1E6BT

  COUNTRY GB

  PHONE +44.442076792171

  EMAIL [email protected]

TECH

  HANDLE C159244488-LRMS

  NAME Ian Sillitoe

  ORGANIZATION The CATH Group

ADDRESS

STREET
Room 627, Darwin Building
Gower Street

  CITY London

  STATE London

  PCODE WC1E6BT

  COUNTRY GB

  PHONE +44.442076792171

  EMAIL [email protected]

BILLING

  HANDLE C159244487-LRMS

  NAME Ian Sillitoe

  ORGANIZATION The CATH Group

ADDRESS

STREET
Room 627, Darwin Building
Gower Street

  CITY London

  STATE London

  PCODE WC1E6BT

  COUNTRY GB

  PHONE +44.442076792171

  EMAIL [email protected]

  REGISTERED yes

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